Trying to figure out how a dome team will fare in inclement weather is always difficult especially if the opposing team ices the field. If anyone is up for the task it's the team at Advanced NFL Stats who tells us there may be something to the idea that dome teams suffer outdoors:
Sample sizes get smaller as the temperature drops. In the 11-20 degree bin, there are 17 cold visitors, 8 dome visitors, 9 moderate visitors, and 6 warm visitors. In the 21-30 bin there were 45, 15, 32, and 19 cold, dome, moderate, and warm visitors. Taken as a whole, however, the trends appear undeniable: The less acclimated a team is to a cold climate, the worse it fairs.